Members of the ARF family are subjected to myristoylation at the N-terminal glycine residue, a lipid co-translational modification that appears essential for functional activity. This myristoylated ARF-6 is a strong inhibitor of calcium-evoked catecholamine secretion and phospholipase D activation in chromaffin cells, the non-myristoylated ARF-6 and the myristolated ARF-1 have mimimal effects.
ARF家族的成员在N-末端甘氨酸残基处进行肉豆蔻酰化,这是一种脂质共翻译修饰,似乎对功能活性至关重要。这种肉豆蔻酰化的ARF-6是嗜铬细胞中钙诱发儿茶酚胺分泌和磷脂酶D激活的强抑制剂,非肉豆蔻酰化ARF-6和肉豆蔻酰化ASF-1的作用很小。
烷基化肽-说明
专肽生物可提供多肽烷基化修饰,增加多肽一端的疏水性,例如常见的C18,C16,C14,C12,以及C6等,也可根据客户要求,接其他长度的烷基化链。