专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

Members of the ARF family are subjected to myristoylation at the N-terminal glycine residue, a lipid co-translational modification that appears essential for functional activity. This myristoylated ARF-6 is a strong inhibitor of calcium-evoked catecholamine secretion and phospholipase D activation in chromaffin cells, the non-myristoylated ARF-6  and the myristolated ARF-1 have mimimal effects.

ARF家族的成员在N-末端甘氨酸残基处进行肉豆蔻酰化，这是一种脂质共翻译修饰，似乎对功能活性至关重要。这种肉豆蔻酰化的ARF-6是嗜铬细胞中钙诱发儿茶酚胺分泌和磷脂酶D激活的强抑制剂，非肉豆蔻酰化ARF-6和肉豆蔻酰化ASF-1的作用很小。

烷基化肽-说明

专肽生物可提供多肽烷基化修饰，增加多肽一端的疏水性，例如常见的C18，C16，C14，C12，以及C6等，也可根据客户要求，接其他长度的烷基化链。

肉豆蔻酸修饰肽说明:
Myristyl group (Myristic acid), CH3(CH2)12–

肉豆蔻酸修饰肽的相关文献:
CPC Scientific serves as a supplier and partner to MYR Pharmaceuticals for developing bulevirtide (Hepcludex).
Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics

Buss, Colin G., and Sangeeta N. Bhatia.  Proceedings of the National Academy of Sciences (2020).
European Commission (EC) Grants Conditional Marketing Authorization (CMA) for MYR Pharmaceuticals HEPCLUDEX®.

A comparison of modular PEG incorporation strategies for stabilization of peptide-siRNA nanocomplexes.
Lo, Justin H., et al. Bioconjugate Chemistry (2016).