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Bax inhibitor peptide V5（BIP V5）是抑制Bax蛋白易位到线粒体中的肽类抑制剂。

Bax是Bcl-2蛋白家族的促凋亡成员，在线粒体依赖性细胞凋亡中起着重要作用。Bax存在于细胞质中，接受细胞凋亡刺激后转移到线粒体中。

BIP V5是细胞膜渗透性的肽类抑制剂，抑制Bax易位到线粒体中。在HeLa细胞中，BIP V5保护细胞免受UVC和STS诱导的细胞凋亡。在U87-MG胶质瘤细胞、MCF-7乳腺癌细胞和LNCaP前列腺癌细胞中，BIP V5也抑制由抗癌药顺铂、依托泊苷和阿霉素诱导的细胞凋亡。在缺乏Bax的细胞（DU145）中，BIP V5不能抑制UVC或STS诱导的细胞凋亡，这表明BIP V5仅抑制Bax蛋白介导的细胞凋亡。同样地，经UVC照射和STS治疗后，BIP（V5）抑制Bax易位到线粒体中。由细胞凋亡刺激引发的线粒体细胞色素c释放以及caspase激活显著地受BIP V5抑制。BIP V5呈剂量依赖性地抑制Ku70与内源性Bax蛋白间相互作用。

在小鼠模型中，BIP V5分别增加超过11倍和3倍的抗凋亡蛋白XIAP和Bcl-2表达，并减少了10%、30%和约50%的细胞凋亡诱导的蛋白表达，包括Bax、Bad以及NF-κB p65。另外，BIP V5增加葡萄糖响应性胰岛素分泌。

Bax抑制剂肽V5醋酸盐是Bax介导的细胞凋亡抑制剂，是Bcl-2家族蛋白的促凋亡成员，在线粒体依赖性细胞凋亡中发挥重要作用。用于癌症治疗。

Bax inhibitor peptide V5 acetate, a Bax-mediated apoptosis inhibitor, is a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. It is used in cancer treatment.

Peptide H-VPMLK-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-VPMLK-OH include the following: PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells Z Liu, H Lu , H Shi, Y Du, J Yu , S Gu, X Chen , KJ Liu - Cancer research, 2005 - AACRhttps://aacrjournals.org/cancerres/article-abstract/65/5/1647/519347 Neuroprotective Effects of Bax-inhibiting Peptides on Hypoxic Damages in Purified Cultured Retinal Ganglion Cells YN Chen, M Aihara, M Araie - & Visual Science, 2005 - iovs.arvojournals.orghttps://iovs.arvojournals.org/article.aspx?articleid=2400793 Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation Y Li, T Yokota, V Gama , T Yoshida, JA Gomez - Cell Death & , 2007 - nature.comhttps://www.nature.com/articles/4402219 Bax Inhibiting Peptides (BIPs) Derived from Ku70 Suppress Chemotherapy Induced-Cell Death of Megakaryocytes. T Yoshida, J Gomez, V Gama , NT Wickramasekera - Blood, 2004 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006497118651602 Bax-inhibiting peptide derived from mouse and rat Ku70 T Yoshida, I Tomioka, T Nagahara, T Holyst - Biochemical and , 2004 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X04015281 Simultaneous quantitation of peptides and phosphopeptides by capLC-ICP-MS using the Agilent 8800 Triple Quadrupole ICP-MS SD Fernandez, N Sugiyama, JR Encinar , A SanzMedel - hpst.czhttps://www.hpst.cz/sites/default/files/oldfiles/5991-1461en-simultaneous-quantitation-peptides-and-phosphopeptides-caplc-icp-ms-using-agilent-8800.pdf Evaluation of online carbon isotope dilution mass spectrometry for the purity assessment of synthetic peptide standards SC DacaÂ\xadaz, JR Encinar , JIG Alonso - Analytica Chimica Acta, 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003267014009271 Recent developments in peptide-based nucleic acid delivery S Veldhoen, SD Laufer, T Restle - International journal of molecular , 2008 - mdpi.comhttps://www.mdpi.com/1422-0067/9/7/1276 Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides S Dissanayake , WA Denny , S Gamage - Journal of Controlled , 2017 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0168365917300603 The role of Bax-inhibiting peptide in retinal ganglion cell apoptosis after optic nerve transection Q Qin, K Patil, SC Sharma - Neuroscience letters, 2004 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0304394004011140 Prediction of drug synergism between peptides and antineoplastic drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin using in silico approaches N Vale , M Pereira, J Santos, C Moura - International Journal of , 2022 - mdpi.comhttps://www.mdpi.com/1422-0067/24/1/69 Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70 M Sawada, P Hayes, S Matsuyama - Nature cell biology, 2003 - nature.comhttps://www.nature.com/articles/ncb955 Two possible strategies for drug modification of gemcitabine and future contributions to personalized medicine M Pereira, N Vale - Molecules, 2022 - mdpi.comhttps://www.mdpi.com/1420-3049/27/1/291 Bax-Inhibiting Peptides Prevents Glutamate-Induced Neurotoxicity in Rat Retina M Ohashi, S Saito, YN Chen - & Visual Science, 2006 - iovs.arvojournals.orghttps://iovs.arvojournals.org/article.aspx?articleid=2394626 27 Cell-Permeable Penta-Peptides Derived from Bax-Inhibiting Peptide JA Gomez, V Gama , S Matsuyama - Half title, 2005 - academia.eduhttps://www.academia.edu/download/49579088/Prediction_of_Cell-Penetrating_Peptides20161013-20725-13wvoss.pdf#page=492 Cell-penetrating penta-peptides (CPP5s): measurement of cell entry and protein-transduction activity JA Gomez, J Chen, J Ngo, D Hajkova, IJ Yeh, V Gama - Pharmaceuticals, 2010 - mdpi.comhttps://www.mdpi.com/1424-8247/3/12/3594 Cell-penetrating penta-peptides and BAX-inhibiting peptides: Protocol for their application J Gomez, S Matsuyama - -Penetrating Peptides: Methods and Protocols, 2011 - Springerhttps://link.springer.com/protocol/10.1007/978-1-60761-919-2_33 Polymer cancerostatics containing cell-penetrating peptides: internalization efficacy depends on peptide type and spacer length E Böhmova, R Pola, M Pechar, J Parnica, D Machova - Pharmaceutics, 2020 - mdpi.comhttps://www.mdpi.com/1999-4923/12/1/59 A MedChem toolbox for cereblon-directed PROTACs C Steinebach , I SosiÃ\x84Â\x8d , S Lindner, A Bricelj , F Kohl - , 2019 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2019/md/c9md00185a Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats C Ma, Y Pan, Z Yang, Z Meng, R Sun, T Wang, Y Fei - Life sciences, 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0024320515300825 Development of potent CPP6-gemcitabine conjugates against human prostate cancer cell line (PC-3) C Correia, CPR Xavier , D Duarte , A Ferreira - RSC Medicinal , 2020 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2020/md/c9md00489k Gemcitabine peptide-based conjugates and their application in targeted tumor therapy A HawryÃ\x85â\x80\x9akiewicz, N PtaszyÃ\x85â\x80\x9eska - Molecules, 2021 - mdpi.comhttps://www.mdpi.com/1420-3049/26/2/364