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An inhibitor of dipeptidyl aminopeptidase IV.

Peptide H-IPI-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-IPI-OH include the following: A proteomics approach to study in vivo protein Nalpha-modifications X Zhang , J Ye, P Hojrup - Journal of Proteomics, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1874391909002589 Identification and characterization of dipeptidyl peptidase-IV inhibitory peptides from oat proteins W Wang, X Liu, Y Li, H You, Z Yu, L Wang, X Liu - Foods, 2022 - mdpi.comhttps://www.mdpi.com/2304-8158/11/10/1406 Solvent Effects on the 310-/alpha-Helix Equilibrium in Short Amphipathic Peptides Rich in alpha,alpha-Disubstituted Amino Acids TS Yokum, TJ Gauthier, RP Hammer - Journal of the , 1997 - ACS Publicationshttps://pubs.acs.org/doi/full/10.1021/ja962875c Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in beta-lactoglobulin ST Silveira, D MartacaÂ\xadnez-Maqueda, I Recio - Food chemistry, 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814613003683 Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism Q Zhu, X Chen, J Wu, Y Zhou, Y Qian, M Fang - Food Research and , 2017 - Springerhttps://link.springer.com/article/10.1007/s00217-017-2879-1 Collagen derived Gly-Pro-type DPP-IV inhibitory peptides: Structure-activity relationship, inhibition kinetics and inhibition mechanism Q Xu, L Zheng, M Huang , M Zhao - Food Chemistry, 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814624000189 IV (DPP-IV) inhibitory peptides derived from tilapia (Oreochromis niloticus) skin gelatin by an integrated approach of multivariate analysis and Gly-Pro-based peptide Q Xu, L Zheng, M Huang , M Zhao - Food Chemistry, 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814622017836 The first structure in a family of peptidase inhibitors reveals an unusual Ig-like fold v2; ref status: indexed NDR Finn - 2013 - researchgate.nethttps://www.researchgate.net/profile/Neil-Rawlings-2/publication/260272656_The_first_structure_in_a_family_of_peptidase_inhibitors_reveals_an_unusual_Ig-like_fold/links/02e7e536cdc2545bf8000000/The-first-structure-in-a-family-of-peptidase-inhibitors-reveals-an-unusual-Ig-like-fold.pdf Relating electrospray ionization response to nonpolar character of small peptides NB Cech , CG Enke - Analytical Chemistry, 2000 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac9914869 Purification and characterization of multifunctional peptides with in situ insulinotropic and antioxidative activity from a blue whiting (Micromesistius poutassou) protein N Shekoohi, P Harnedy-Rothwell, S Sharkey - Journal of Functional , 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1756464624001750 Rapid Screening of Novel Dipeptidyl Peptidase-4 Inhibitory Peptides from Pea (Pisum sativum L.) Protein Using Peptidomics and Molecular Docking M Zhang, L Zhu, G Wu, T Liu, X Qi - Journal of Agricultural , 2022 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.2c03949 Ion-pair mediated transport of small model peptides in liquid phase micro extraction under acidic conditions JLE Reubsaet , JV Paulsen - Journal of separation science, 2005 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.200401779 Investigation into the bioavailability of milk protein-derived peptides with dipeptidyl-peptidase IV inhibitory activity using Caco-2 cell monolayers IME Lacroix, XM Chen , DD Kitts , ECY Li-Chan - Food & Function, 2017 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2017/fo/c6fo01411a Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides IME Lacroix, ECY Li-Chan - Peptides, 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978115000741 Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins IME Lacroix, ECY Li-Chan - Peptides, 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978114000059 Identification and quantification of DPP-IV-inhibitory peptides from hydrolyzed-rapeseed-protein-derived napin with analysis of the interactions between key residues F Xu, Y Yao, X Xu, M Wang, M Pan, S Ji - Journal of agricultural , 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b01069 Molecular Mechanistic Insights into Dipeptidyl Peptidase-IV Inhibitory Peptides to Decipher the Structural Basis of Activity C Wang, L Zheng, CC Udenigwe , L Lin - Journal of Agricultural , 2024 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.3c08791 In silico study to predict potential precursors of human dipeptidyl peptidase-IV inhibitors from hazelnut C Li, R Qi, J Yuan, L Han , S Wang, W Li - Journal of Biomolecular , 2022 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/07391102.2021.1961868 Strategic preparations of DPP-IV inhibitory peptides from Val-Pro-Xaa and Ile-Pro-Xaa peptide mixtures C Guan , S Iwatani, X Xing, N Yamamoto - International Journal of Peptide , 2021 - Springerhttps://link.springer.com/article/10.1007/s10989-020-10122-7 Evidence for the extent of insertion of the active site loop of intact. alpha. 1 proteinase inhibitor in. beta.-sheet A AJ Schulze, PW Frohnert, RA Engh, R Huber - Biochemistry, 1992 - ACS Publicationshttps://pubs.acs.org/doi/pdf/10.1021/bi00148a017 Identification of novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in camel milk protein hydrolysates AB Nongonierma , S Paolella, P Mudgil , S Maqsood - Food Chemistry, 2018 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814617316692 DPP-4 Cleaves alpha/beta-Peptide Bonds: Substrate Specificity and Half-Lives A TuraliÃ\x84â\x80¡ , J Ã\x84Â\x90eÃ\x84â\x80\x98ibegoviÃ\x84â\x80¡ , Z Hegedus - Chembiochem, 2020 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.202000050 Bioinformatics Analysis of IPIs in Five Northern Medicinal Plants A Hao, H Qi, H Guo, J Wei - Agricultural Science & Technology, 2016 - search.proquest.comhttps://search.proquest.com/openview/554f0f04d23171883a096b897cc2b297/1?pq-origsite=gscholar&cbl=1596357

Diprotin A is a peptide that is involved in cell signaling and has been shown to interact with ion channels and receptors. It is an activator of the Fc receptor, which is responsible for the activation of immune cells. This peptide can also be used as a research tool to study protein interactions or as an antibody to study ligands or receptors. Diprotin A can be used in the pharmacological treatment of diseases such as cancer, inflammation, and pain.

Dpp-iv is a serine protease enzyme that is important for the production of vasoactive peptides and inflammatory mediators. It is involved in the regulation of heart function, blood pressure, and vascular tone. Inhibitors of Dpp-iv have been shown to be useful in the treatment of a variety of diseases including hypertension, coronary artery disease, myocardial infarction, and stroke. Diprotin A is a synthetic inhibitor that has been shown to prevent adenoviral vector-mediated heart damage in neonatal animals. This drug also inhibits the production of vasoactive peptides and inflammatory mediators by blocking Dpp-iv activity, preventing cardiac dysfunction following an infarction.