An inhibitor of dipeptidyl aminopeptidase IV.
编号：138690
CAS号：90614-48-5
单字母：H2N-IPI-OH
| 编号: | 138690 |
| 中文名称: | 抑二肽素A、Diprotin A |
| 英文名: | Diprotin A |
| CAS号: | 90614-48-5 |
| 单字母: | H2N-IPI-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 3 |
| 分子式: | C17H31N3O4 |
| 平均分子量: | 341.45 |
| 精确分子量: | 341.23 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.8 |
| 疏水性值: | 2.47 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 三肽 |
An inhibitor of dipeptidyl aminopeptidase IV.
| DOI | 名称 | |
|---|---|---|
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| 10.2337/diacare.26.3.837 | Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes | 下载 |
| 10.1128/AAC.49.3.1087-1092.2005 | Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium | 下载 |
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| 10.1016/j.neuint.2006.05.006 | The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats | 下载 |
| 10.1021/jm0606490 | Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach | 下载 |
| 10.1089/scd.2007.9997 | Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells | 下载 |
| 10.1016/j.peptides.2007.07.012 | Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats | 下载 |
| 10.33549/physiolres.931231 | Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines | 下载 |
| 10.1152/ajpendo.90233.2008 | Incretin and islet hormonal responses to fat and protein ingestion in healthy men | 下载 |
| 10.1007/s11064-008-9853-z | The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats | 下载 |
| 10.1016/j.exphem.2009.03.005 | Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A | 下载 |
| 10.1038/oby.2009.378 | Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats | 下载 |
| 10.1210/jc.2011-0266 | Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans | 下载 |
| 10.1016/j.biocel.2012.01.011 | Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity | 下载 |
| 10.1016/j.molmet.2013.11.010 | Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency | 下载 |
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| 10.7164/antibiotics.37.422 | Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria | 下载 |
| 10.1016/s0014-5793(98)00515-8 | Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens | 下载 |
