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Cytochrome c-pigeon (88-104) (PCC 88-104) 对 B10.A 小鼠鸽细胞色素c-启动的T细胞具有完全的刺激活性。对 Cytochrome c pigeon 反应的 I-Ek 限制性T细胞对 88-104 中具有特异性。
Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-Ek-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104.

氨基酸序列为H-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH。

I-Ek-限制性T细胞对细胞色素C - 鸽子（pcyt c）COOH末端88-104[1]多肽的应答是特异的。

T细胞激活所需的pcyt C多肽的最小长度为COOH末端序列含有的残基95-104。然而，残基95的NH2末端加入额外的残基可增加肽的抗原效力，最大效应是由pcyt c 88-104引起的。

取代细胞色素C多肽95到104之间的任何一个残基可以改变细胞色素C多肽对至少一种杂交瘤的抗原性。

Peptide H-KAERADLIAYLKQATAK-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-KAERADLIAYLKQATAK-OH include the following: Instruction of naive CD4+ T cells by polarized CD4+ T cells within dendritic cell clusters RJ Creusot , JS Biswas , LL Thomsen - European journal of , 2003 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/eji.200323811 Peptide fingerprints after partial acid hydrolysis: Analysis by matrix-assisted laser desorption/ionization mass spectrometry MD Knierman , JE Coligan, KC Parker - in Mass Spectrometry, 1994 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.1290081220 Analysis of Vbeta4 T cell receptor CDR3 repertoire in BALB/c and (NZBacaâ\x80\x94 NZW) F1 mice M Fukuoka, M Tokushima, S Koarada , T Sai, K Miyake - Immunology letters, 1997 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0165247897001016 Stabilization of helical structure in two 17-residue amphipathic analogues of the C-terminal peptide of cytochrome c JF Collawn , Y Paterson - Biopolymers: Original Research on , 1990 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/bip.360290817 Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes HG Kasler, E Verdin - Molecular and cellular biology, 2007 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1128/MCB.02091-06 Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens: A Model to Explain GS Vratsanos, S Jung , YM Park, J Craft - The Journal of Experimental , 2001 - rupress.orghttps://rupress.org/jem/article-abstract/193/3/329/39354 Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists. DM Page , J Alexander, K Snoke - Proceedings of the , 1994 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.91.9.4057 SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+ CD8+ DPK thymocytes differentiation DM Lee, SH Lee, KT Jeong, SJ Hwang - Environmental Toxicology , 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1382668912001305 Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands DB Wilson, C Pinilla , DH Wilson - The Journal of , 1999 - journals.aai.orghttps://journals.aai.org/jimmunol/article/163/12/6424/7142 Induction of S100A4, S100A6, and galectin-1 during the lineage commitment of CD4+ CD8+ thymocyte cell line is suppressed by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin CH Jeon, HL Kim, JH Park - Toxicology letters, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0378427409001180 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3, transcription regulatory factors controlling the lineage commitment of CD4+ BC Gill, CH Jeon, HN Sung, HL Kim, DW Jin, JH Park - Toxicology letters, 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0378427408010370 Strong induction of tyrosine phosphorylation, intracellular calcium, nuclear transcription factors and interferonγ, but weak induction of IL-2 in naÃ\x84±Ã\x8cË\x86ve T cells stimulated A Luxembourg, H Grey - Cellular immunology, 2002 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0008874902005816

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