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Dynamin inhibitory peptide 竞争性地阻止了动力蛋白 (dynamin) 与两性纤维蛋白的结合，从而防止了内吞作用。Dynamin inhibitory peptide 阻断多巴胺 D3 对 GABAA 受体的作用。
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors[1].

动力素抑制肽是GTPase动力素的多肽抑制剂，氨基酸序列为Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro。

动力素是一个100 kDa的较大的GTP酶，其功能是释放来自于高尔基体和细胞质膜新生囊泡。动力素在细胞器的分裂、胞质分裂和微生物病原体抗性等过程中发挥重要作用。

动力素多肽抑制剂竞争性阻断动力素与amphiphysin蛋白的结合，当胞内给药时，可以防止内吞作用。在表达GABAA受体的神经元中，可以减少GABA受体的内化和增加mISPC的幅度和频率。

Peptide H-QVPSRPNRAP-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-QVPSRPNRAP-OH include the following: Glycine binding primes NMDA receptor internalization Y Nong, YQ Huang, W Ju, LV Kalia , G Ahmadian - Nature, 2003 - nature.comhttps://www.nature.com/articles/nature01497 Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons XY Zhang, F Ji , N Wang, LL Chen, T Tian - Journal of Biological , 2014 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)33349-4/abstract Retrieval-extinction of drug memory requires AMPA receptor trafficking X Lv, J Zhang, TF Yuan - Science Advances, 2022 - science.orghttps://www.science.org/doi/abs/10.1126/sciadv.add6642 Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells WJ Jockusch, GJK Praefcke, HT McMahon, L Lagnado - Neuron, 2005 - cell.comhttps://www.cell.com/neuron/pdf/S0896-6273(05)00399-5.pdf Endocytic pathways in the long-cultured sympathetic neuron W Lu, S Mochida - Proceedings of Annual Meeting of the , 2008 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/psjproc/2008/0/2008_0_123_2/_article/-char/ja/ Dynamin and activity regulate synaptic vesicle recycling in sympathetic neurons W Lu, H Ma , ZH Sheng, S Mochida - Journal of biological chemistry, 2009 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)82211-1/abstract A Human Mutation in Gabrg2 Associated with Generalized Epilepsy Alters the Membrane Dynamics of GABAA Receptors W Bouthour, F Leroy , C Emmanuelli, M Carnaud - Cerebral , 2012 - academic.oup.comhttps://academic.oup.com/cercor/article-abstract/22/7/1542/291694 Dynamin Is a Key Molecule to Decode Action Potential Firing S Tanifuji, S Mochida - Presynaptic Terminals, 2015 - Springerhttps://link.springer.com/chapter/10.1007/978-4-431-55166-9_11 The formation of small aggregates contributes to the neurotoxic effects of tau45-230 S Afreen, A Ferreira - Neurochemistry international, 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0197018621002989 Mechanisms of homomeric alpha1 glycine receptor endocytosis R Huang, S He , Z Chen, GH Dillon - Biochemistry, 2007 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi701093j Thyrotropin-releasing hormone increases GABA release in rat hippocampus PY Deng, JE Porter, HS Shin , S Lei - The Journal of physiology, 2006 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.2006.118141 Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization P Zhong, W Liu, Z Gu, Z Yan - The Journal of physiology, 2008 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.2008.155143 Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPEThttps://molpharm.aspetjournals.org/content/72/1/40.short Role of cholinoceptors recycling in short-term potentiation of cholinosensitivity of command neurons in edible snail MS Abramova, DA Makhnovskii - Bulletin of Experimental , 2007 - Springerhttps://link.springer.com/article/10.1007/s10517-007-0309-2 Phosphatidylinositol (4, 5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons M Mandal, Z Yan - Molecular pharmacology, 2009 - ASPEThttps://molpharm.aspetjournals.org/content/76/6/1349.short Neural activity selects myosin IIB and VI with a specific time window in distinct dynamin isoform-mediated synaptic vesicle reuse pathways M Hayashida, S Tanifuji, H Ma , N Murakami - Journal of , 2015 - Soc Neurosciencehttps://www.jneurosci.org/content/35/23/8901.short Nucleus accumbens long-term depression and the expression of behavioral sensitization K Brebner, TP Wong , L Liu, Y Liu, P Campsall, S Gray - Science, 2005 - science.orghttps://www.science.org/doi/abs/10.1126/science.1116894 Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins J Xia , HJ Chung , C Wihler, RL Huganir , DJ Linden - Neuron, 2000 - cell.comhttps://www.cell.com/neuron/pdf/S0896-6273(00)00128-8.pdf GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured by fear-potentiated startle HC Lin, YC Tseng , SC Mao, PS Chen - Journal of , 2011 - Soc Neurosciencehttps://www.jneurosci.org/content/31/24/8851.short Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum H Tong, AJ Gibb - The Journal of physiology, 2008 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.2008.158931 Oral Communications-Membrane trafficking and surface dynamics of neurotransmitter receptors 3P H Tong, AJ Gibb - J Neurosci, 2003 - static.physoc.orghttps://static.physoc.org/app/uploads/2019/01/22204014/ucl06_memtraf.pdf Modulation of NMDA receptor activity by dopamine receptors in the rat striatum H Tong - 2006 - search.proquest.comhttps://search.proquest.com/openview/d182b7b38277efa9cd87345ea45d1866/1?pq-origsite=gscholar&cbl=2026366&diss=y Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens G Chen, JT Kittler , SJ Moss , Z Yan - Journal of Neuroscience, 2006 - Soc Neurosciencehttps://www.jneurosci.org/content/26/9/2513.short Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors EY Yuen, Z Yan - Journal of Biological Chemistry, 2011 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)48657-2/abstract A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis DJ Linden - Journal of neurophysiology, 2012 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/jn.00824.2011 Amyloid-beta impairs synaptic inhibition via GABAA receptor endocytosis D Ulrich - Journal of Neuroscience, 2015 - Soc Neurosciencehttps://www.jneurosci.org/content/35/24/9205.short Synthesis and binding properties of peptidomimetics based on a dendritic polymer C Kojima, H Fukada, T Inui - Polymer journal, 2013 - nature.comhttps://www.nature.com/articles/pj2012141 Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons BL Kelly, A Ferreira - Neuroscience, 2007 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0306452207003107 Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals B Marks, HT McMahon - Current biology, 1998 - cell.comhttps://www.cell.com/current-biology/pdf/S0960-9822(98)70297-0.pdf Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones AR Wild , S Jones, AJ Gibb - The Journal of physiology, 2014 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.2013.267310