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肽5是一种连接蛋白43模拟肽。肽5可减轻脊髓损伤后的肿胀、星形胶质细胞增生、神经炎症和神经元细胞死亡。肽5在神经性疼痛模型中表现出镇痛作用。
Peptide5 is a connexin43 mimetic peptide. Peptide5 reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Peptide5 exhibits analgesic effects in models of neuropathic pain.

"Peptide H-VDCFLSRPTEKT-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-VDCFLSRPTEKT-OH include the following: Cytotoxicity and vitreous stability of chemically modified connexin43 mimetic peptides for the treatment of optic neuropathy YS Chen, I Toth , HV Danesh-Meyer, CR Green - Journal of , 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0022354915310479 Characterising the molecular mode of action of connexin therapeutics for the treatment of retinal injury and disease YR Kim - 2016 - researchspace.auckland.ac.nzhttps://researchspace.auckland.ac.nz/handle/2292/30999 Systemic administration of connexin43 mimetic peptide improves functional recovery after traumatic spinal cord injury in adult rats Y Mao, RS Tonkin, T Nguyen, SJ OCarroll - Journal of , 2017 - liebertpub.comhttps://www.liebertpub.com/doi/abs/10.1089/neu.2016.4625 Characterizing the mode of action of extracellular Connexin43 channel blocking mimetic peptides in an in vitro ischemia injury model Y Kim, JM Griffin , PWR Harris , SHC Chan - et Biophysica Acta (BBA , 2017 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0304416516304044 Peptidic connexin43 therapeutics in cardiac reparative medicine SR Marsh, ZJ Williams , KJ Pridham - Journal of cardiovascular , 2021 - mdpi.comhttps://www.mdpi.com/2308-3425/8/5/52 Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury SJ OCarroll , CA Gorrie , S Velamoor, CR Green - Neuroscience , 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0168010213000060 Synthesis and biological evaluation of S-lipidated lipopeptides of a connexin 43 channel inhibitory peptide SH Yang, CA Clemett , MA Brimble - RSC Medicinal , 2020 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2020/md/d0md00172d Roles of gap junctions, connexins, and pannexins in epilepsy S Mylvaganam , M Ramani , M Krawczyk - Frontiers in , 2014 - frontiersin.orghttps://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2014.00172 Connexin targeting peptides as inhibitors of voltage-and intracellular Ca2+-triggered Cx43 hemichannel opening N Wang, M De Bock, E Decrock, M Bol , A Gadicherla - , 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0028390813003882 The lipidated connexin mimetic peptide SRPTEKT-Hdc is a potent inhibitor of Cx43 channels with specificity for the pS368 phospho-isoform ML Cotter, S Boitano, PD Lampe - of Physiology-Cell , 2019 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/ajpcell.00160.2019 Cell-to-Cell Communication and Signaling Pathways: Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation ML Cotter, S Boitano, J Vagner - American Journal of , 2018 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139506/ Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation ML Cotter, S Boitano, J Vagner - American Journal of , 2018 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/ajpcell.00156.2017 Development of Potent, Conformation-Specific Inhibitors of Connexin-Mediated Communication ML Cotter - 2018 - search.proquest.comhttps://search.proquest.com/openview/bd62517d1f1e7ec498c46935e566d97b/1?pq-origsite=gscholar&cbl=18750 9 10 11 Maura L. Cotter, Scott Boitano, Josef Vagner 3, 4, and Janis M. Burt 12 13 JM Burt - journals.physiology.orghttps://journals.physiology.org/doi/prev/20180406-aop/epdf/10.1152/ajpcell.00156.2017 Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion JJ Yoon, CR Green , SJ OCarroll , LFB Nicholson - Epilepsy research, 2010 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0920121110002408"