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TLQP-21 是 VGF 衍生的具有内分泌和内分泌特性的肽，是一种强效的 G 蛋白偶联受体补体 3a 受体 1 (C3aR1) 激动剂 (EC50：小鼠 TLQP-21=10.3 μM；人 TLQP-21=68.8 μM)。TLQP-21 激活 C3aR1，从而诱导细胞内 Ca2+ 的增加。TLQP-21 可用于研究调节伤害感受和其他相关生理功能。
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions.

VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. Increases energy expenditure and prevents early phase diet-induced diabetes.

Peptide H-TLQPPASSRRRHFHHALPPAR-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-TLQPPASSRRRHFHHALPPAR-OH include the following: JMV5656, a novel derivative of TLQP-21, triggers the activation of a calcium-dependent potassium outward current in microglial cells I Rivolta, A Binda, L Molteni, L Rizzi - Frontiers in cellular , 2017 - frontiersin.orghttps://www.frontiersin.org/articles/10.3389/fncel.2017.00041/full The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism C Cero , VV Vostrikov, R Verardi , C Severini - Structure, 2014 - cell.comhttps://www.cell.com/structure/pdf/S0969-2126(14)00324-4.pdf Mechanisms of the pro-lipolytic and anti-obesity effects of the VGF-derived peptide TLQP-21 C Cero - 2015 - conservancy.umn.eduhttps://conservancy.umn.edu/handle/11299/175706 The molecular identity of the TLQP-21 peptide receptor BS Sahu , ME Nguyen, P Rodriguez, JP Pallais - Cellular and Molecular , 2021 - Springerhttps://link.springer.com/article/10.1007/s00018-021-03944-1 TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity A Bartolomucci , G La Corte - Proceedings of the , 2006 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.0606102103 Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice A Bartolomucci , AE Rigamonti , I Bulgarelli - Growth hormone & IGF , 2007 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1096637407000378

Elena Bresciani , et al. TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling. Int J Mol Sci. 2019 Dec 24;21(1):130. : https://pubmed.ncbi.nlm.nih.gov/31878142/
Cheryl Cero, et al. The TLQP-21 Peptide Activates the G-protein-coupled Receptor C3aR1 via a Folding-Upon-Binding Mechanism. ructure. 2014 Dec 2;22(12):1744-1753. : https://pubmed.ncbi.nlm.nih.gov/25456411/