可渗透细胞的九精氨酸酰胺，它可以很容易地与货物分子结合，例如,通过马来酰亚胺-硫醇偶联。
编号：200085
CAS号：1417221-06-7
单字母：H2N-C(Npys)-RRRRRRRRR-CONH2
可渗透细胞的九精氨酸酰胺，它可以很容易地与货物分子结合，例如,通过马来酰亚胺-硫醇偶联。
Cell-permeable nonaarginine amide, which can be easily conjugated to a cargo molecule, e.g. by maleimide-thiol coupling.
它是一种由9个精氨酸残基组成的肽，由活化的半胱氨酸残基C（Npys）合成，其中Npys是3-硝基-2-吡啶磺酰基保护性半胱氨酸。这种含半胱氨酸的9R的S（Npys）基团能够选择性地与另一种含半胱氨酸的肽的游离巯基反应以形成不对称的二硫键。巯基的偶联已被研究为在细胞内的还原环境中递送/释放治疗剂如siRNA的有效手段。
It is a peptide composed of 9 arginine residues synthesized from an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl protective cysteine. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutic agents such as siRNA in the reducing environment within the cell.
| DOI | 名称 | |
|---|---|---|
| 10.1002/chem.201201805 | Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex | 下载 |
| 编号 | 名称 | CAS号 |
| 192212 | 细胞穿透肽八聚精氨酸、Octaarginine、R8、Arg8、(Arg)8 | 148796-86-5 |
| H2N-RRRRRRRR-OH | ||
| 细胞穿透肽八精氨酸是蛋白酶体活性的有效抑制剂。阳性电荷序列。 | ||
| 426207 | 3Mal-Arg8-COOH | |
| 3Mal-RRRRRRRR-OH | ||
