小胰高血糖素抑制Ca 2+活化的和Mg 2+依赖性的ATPase活性以及Ca 2+在肝脏质膜中的转运，其效率比胰高血糖素高1000倍。
编号：164464
CAS号：64790-15-4
单字母：H2N-AQDFVQWLMNT-OH
微量胰高血糖素抑制⁺ 活化和Mg²⁺ 依赖性ATP酶活性和Ca²⁺ 以比胰高血糖素高1000倍的效率在肝质膜中转运。它可能是参与抑制肝脏Ca²的活性肽⁺ 抽水机微量胰高血糖素是胰高血糖原的最终加工产物，是胰岛生理的调节因子。
Miniglucagon inhibited both the Ca²⁺ activated and Mg²⁺ dependent ATPase activity and Ca²⁺ transport in liver plasma membranes with an efficiency 1000-fold higher than that of glucagon. It is likely to be the active peptide involved in the inhibition of the liver Ca²⁺ pump. Miniglucagon, the ultimate processing product of proglucagon, is a regulator of the pancreatic islet physiology.
Glucagon是由胰腺分泌的一种肽类激素，氨基酸序列为NH2-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-COOH，可增加体内血糖水平。胰高血糖素的作用与胰岛素相反，胰岛素可以降低血糖含量。促分泌素可诱导胰岛素释放，Miniglucagon（胰高血糖素19-29）通过钙离子途径高效的抑制这个过程。Miniglucagon是胰岛生理学的一种新型的局部调节剂。在2型糖尿病中观察到，这种肽在β细胞中诱导的异常抑制可导致胰岛素分泌受损。Miniglucagon是胰高血糖素正性肌力作用的一种成分。证据表明，胰高血糖素在心脏收缩过程中发挥正性肌力作用，胰高血糖素转变成miniglucagon的过程对于正向肌力作用的产生是必不可少的。
参考文献：
1. Reece J, Campbell N (2002). Biology. San Francisco: Benjamin Cummings. ISBN 0-8053-6624-5.
2. Stéphane Dalle, Ghislaine Fontés, Anne-Dominique Lajoix2, Laurence LeBrigand, René Gross, Gérard Ribes, Michel Dufour, Léo Barry, Dung LeNguyen and Dominique Bataille, Miniglucagon (Glucagon 19-29) A Novel Regulator of the Pancreatic Islet Physiology, doi:10.2337/diabetes.51.2.406Diabetes February 2002 vol. 51 no. 2406-412
3. Pavoine C, Brechler V, Kervan A, Blache Kervan, Le-Nguyen D, Laurent S, Bataille D, Pecker F (1991) Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol 260:C993–C999.
| DOI | 名称 | |
|---|---|---|
| 10.1074/jbc.274.16.10869 | Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway | 下载 |
| 10.2337/diabetes.51.2.406 | Miniglucagon (glucagon 19-29): a novel regulator of the pancreatic islet physiology | 下载 |
| 10.1167/iovs.04-1027 | Glucagon- and secretin-related peptides differentially alter ocular growth and the development of form-deprivation myopia in chicks | 下载 |
| 10.1196/annals.1317.005 | The glucagon-miniglucagon interplay: a new level in the metabolic regulation | 下载 |
| 10.1038/325620a0 | A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon | 下载 |
| 10.1152/ajpcell.1991.260.5.C993 | Miniglucagon glucagon-(19-29) is a component of the positive inotropic effect of glucagon | 下载 |
