Amyloid β-Protein (10-20)是淀粉样β肽的一个片段，可用于神经系统疾病的研究。
编号：162454
CAS号：152286-31-2
单字母：H2N-YEVHHQKLVFF-OH
Amyloid β-Protein (10-20) 是 β 淀粉样肽的一个片段，在神经领域具有潜在的作用。
Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
在阿尔茨海默病（AD）中，β-淀粉样蛋白(Aβ）可以引发神经退行性病变 1。在非正常生理条件下，由β淀粉样前体蛋白(β-amyloid precursor protein,APP)水解产生，是一种分解代谢副产物2。
Aβ是许多不同受体和其它分子的配体3-5，通过复杂转运通路在组织和血脑屏障中运输。Aβ响应于各种不同的环境压力，能够诱导促炎活性7。
可溶性β淀粉样多肽片段是明胶酶A/ IV型胶原酶/MMP-2及APP分泌酶的底物，作用于Lys16和Leu17之间，使蛋白断裂。
淀粉样β-乙酸蛋白（10-20）是淀粉样β肽的一个片段，可用于神经系统疾病的研究。
Amyloid β-Protein (10-20) acetate is a fragment of Amyloid β peptide that may be used in the study of neurological diseases.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.chroma.2017.05.069 | Determination of acidity constants and prediction of electrophoretic separation of amyloid beta peptides | 下载 |
| 10.1038/35086072 | Alzheimer’s disease and Aβ-toxicity: From top to bottom. | 下载 |
| 10.1523/JNEUROSCI.21-02-j0003.2001 | Amyloid (b)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1 | 下载 |
| 10.1021/bi002186k | Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits Ab aggregation and toxicity. | 下载 |
| 10.1111/j.1471-4159.2004.02818.x | Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. | 下载 |
| 10.1016/j.neuron.2004.08.024 | Clearance of Alzheimer’s Ab peptide: the many roads to perdition. | 下载 |
| 10.1006/exnr.1999.7055 | Inhibition of Alzheimer’s b-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism. | 下载 |
