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Gap 27，一种合成的 connexin43 模拟肽，是一种间隙连接抑制剂。Gap 27 与通往第二跨膜连接蛋白区段的第二细胞外环的一部分具有保守的序列同源性。
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment.

Gap 27是来源于connexin 43的多肽（Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile），是缝隙连接的选择性阻断剂。

连接蛋白，或缝隙连接是结构上相关的跨膜蛋白家族。缝隙连接包含允许离子和小分子通过相邻细胞的通道。这种细胞间的通讯可协调细胞对细胞内的信号分子做出响应。钙和肌醇磷酸是可以通过间隙连接通道的第二信使。这种合成的连接蛋白模拟肽，Gap 27，被用于评估间隙连接通讯对破骨细胞骨吸收的贡献。结果表明，间隙连接通讯对于适当的骨重塑是必须的。

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Peptide H-SRPTEKTIFII-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-SRPTEKTIFII-OH include the following: Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration S Zahler, A Hoffmann, T Gloe - Journal of Leucocyte , 2003 - academic.oup.comhttps://academic.oup.com/jleukbio/article-abstract/73/1/118/6979332 Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8+ T cells S Ring, S Karakhanova, T Johnson, AH Enk - Journal of Allergy and , 2010 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0091674909015541 Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells S Pollok, AC Pfeiffer, R Lobmann - Journal of cellular , 2011 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1582-4934.2010.01057.x Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation N Wang, M De Bock, G Antoons , AK Gadicherla - Basic research in , 2012 - Springerhttps://link.springer.com/article/10.1007/s00395-012-0304-2 The lipidated connexin mimetic peptide SRPTEKT-Hdc is a potent inhibitor of Cx43 channels with specificity for the pS368 phospho-isoform ML Cotter, S Boitano, PD Lampe - of Physiology-Cell , 2019 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/ajpcell.00160.2019 Channels and Transporters in Cell Signaling: The lipidated connexin mimetic peptide SRPTEKT-Hdc is a potent inhibitor of Cx43 channels with specificity for ML Cotter, S Boitano, PD Lampe , JL Solan - American Journal of , 2019 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850999/ Cell-to-Cell Communication and Signaling Pathways: Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation ML Cotter, S Boitano, J Vagner - American Journal of , 2018 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139506/ Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation ML Cotter, S Boitano, J Vagner - American Journal of , 2018 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/ajpcell.00156.2017 Development of Potent, Conformation-Specific Inhibitors of Connexin-Mediated Communication ML Cotter - 2018 - search.proquest.comhttps://search.proquest.com/openview/bd62517d1f1e7ec498c46935e566d97b/1?pq-origsite=gscholar&cbl=18750 Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide KA Dora , PEM Martin , AT Chaytor , WH Evans - Biochemical and , 1999 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X98998771 Connexin 43 mediates spread of Ca2+ -dependent proinflammatory responses in lung capillaries K Parthasarathi, H Ichimura, E Monma - The Journal of , 2006 - Am Soc Clin Investighttps://www.jci.org/articles/view/26605 Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption K Boengler, M Ruiz-Meana, S Gent - Journal of cellular , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1582-4934.2011.01516.x The lipidated connexin mimetic peptide, SRPTEKT-Hdc, is a potent inhibitor of Cx43 channels 2 with specificity for the pS368 phospho-isoform 3 4 Maura L. Cotter1 JM Burt - journals.physiology.orghttps://journals.physiology.org/doi/prev/20190731-aop/epdf/10.1152/ajpcell.00160.2019 9 10 11 Maura L. Cotter, Scott Boitano, Josef Vagner 3, 4, and Janis M. Burt 12 13 JM Burt - journals.physiology.orghttps://journals.physiology.org/doi/prev/20180406-aop/epdf/10.1152/ajpcell.00156.2017 Connexin-mimetic peptide Gap 27 decreases osteoclastic activity J Ilvesaro, P Tavi , J Tuukkanen - BMC musculoskeletal disorders, 2001 - Springerhttps://link.springer.com/article/10.1186/1471-2474-2-10 Control of the proliferation of activated CD4+ T cells by connexins E Oviedo-Orta, M Perreau, WH Evans - Journal of leukocyte , 2010 - academic.oup.comhttps://academic.oup.com/jleukbio/article-abstract/88/1/79/6959872 Gap junction intercellular communication during lymphocyte transendothelial migration E Oviedo-Orta, RJ Errington - Cell biology , 2002 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1006/cbir.2001.0840 Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication E OVIEDO-ORTA, P Gasque - The FASEB , 2001 - Wiley Online Libraryhttps://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.00-0288com Cx43 in mesenchymal stem cells promotes angiogenesis of the infarcted heart independent of gap junctions DG Wang, FX Zhang, ML Chen - Molecular , 2014 - spandidos-publications.comhttps://www.spandidos-publications.com/mmr/9/4/1095 The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro CS Wright , S Pollok, DJ Flint - Journal of cellular , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.22705 Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro CS Wright , MAM Van Steensel - Wound repair and , 2009 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-475X.2009.00471.x Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries AT Chaytor , WH Evans, TM Griffith - The Journal of physiology, 1998 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7793.1998.561bq.x The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication AT Chaytor , PEM Martin , WH Evans - The Journal of , 1999 - Wiley Online Libraryhttps://physoc.onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7793.1999.00539.x Communication via connexin 43-containing gap junction is inhibitory to collagen production by tendon cells in vitro AD Waggett, M Benjamin, JR Ralphs - Trans. Orthop. Res. Soc, 2001 - ors.orghttps://www.ors.org/transactions/47/0700.pdf