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Thrombin Receptor Activator for Peptide 5 (TRAP-5) 又叫作凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5) (Proteinase Activated Receptor 1 (1-5))，可用于冠心病的研究。
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

凝血因子II（凝血酶）受体是G蛋白偶联受体，参与调节血栓反应。蛋白水解引发受体的激活。

在血小板中，凝血酶有助于止血和血栓形成。内皮细胞的PARs参与血管张力和渗透性的调控，在血管平滑肌中，参与调节收缩、增生和肥大。在动脉粥样硬化和心瓣手术后的再狭窄中，PARs参与了促炎反应。近期研究揭示了这种新型受体在肌肉生长、骨细胞的分化和细胞增殖中的作用。

在T细胞中， PAR1、PAR2和PAR3的活化诱导了VAV1的酪氨酸磷酸化。PARs的活化也导致ZAP-70和SLP-76酪氨酸磷酸化的增加，这两个蛋白是T细胞受体信号（TCR）的关键蛋白。

肽TFA凝血酶受体激活剂是一种用于冠心病研究的凝血酶受体激活物。凝血酶受体是一种G蛋白偶联受体，参与血栓反应的调节。

Thrombin Receptor Activator for Peptide TFA is a thrombin receptor activator used in the research of coronary heart disease (CHD). The thrombin receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

H-Ser-Phe-Leu-Leu-Arg-OH is a cyclic peptide that has been shown to have cytotoxic effects against cells of the atherosclerotic lesion in vivo. It also has antioxidant properties and can be used as a biocompatible polymer for the treatment of autoimmune disease. This drug is not potent enough to be used as an antibacterial agent but is effective against some strains of Mycobacterium tuberculosis and Mycobacterium avium complex. This drug binds to integrin receptors on cells, which may account for its low potency.