400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
研究表明，Amyloid β-Protein (17-21)在淀粉样变的大鼠模型中，β-Sheet Breaker Peptide显著减少体内β淀粉样蛋白的沉积，完全阻止淀粉样蛋白原纤维的形成。
编号：110189
CAS号：182912-74-9/2763585-09-5
单字母：H2N-LPFFD-OH
| 编号: | 110189 |
| 中文名称: | 抑制淀粉样蛋白生成的多肽 Beta-Sheet Breaker Peptide iAβ5、Aβ (17-21) |
| 英文名: | (Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) |
| 英文同义词: | Fibrillogenesis inhibitor III、IAβ5 |
| CAS号: | 182912-74-9，free base 2763585-09-5，醋酸盐 |
| 单字母: | H2N-LPFFD-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -PheL-苯丙氨酸：phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：F，Phe。 -PheL-苯丙氨酸：phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：F，Phe。 -AspL-天冬氨酸：aspartic acid。系统命名为(2S)-氨基-丁二酸。是编码氨基酸，又是神经递质。符号：D，Asp。D-天冬氨酸存在于多种细菌的细胞壁和短杆菌肽A中。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 5 |
| 分子式: | C33H43N5O8 |
| 平均分子量: | 637.72 |
| 精确分子量: | 637.31 |
| 等电点(PI): | 6.26 |
| pH=7.0时的净电荷数: | -0.02 |
| 平均亲水性: | -0.95 |
| 疏水性值: | 0.86 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 未分类肽 |
The pentapeptide LPFFD (iAβ5), a highly efficient β-sheet breaker, inhibited amyloid formation in vitro, prevented amyloid neurotoxicity in cell culture, reduced in vivo cerebral Aβ deposition and completely blocked amyloid fibril formation in rat brain.
β-Sheet Breaker Peptide iAβ5的化学式为C33H43N5O8，多肽序列为H-Leu-Pro-Phe-Phe-Asp-OH。在大鼠模型中，它能抑制淀粉样蛋白的生成。研究表明，在淀粉样变的大鼠模型中，β-Sheet Breaker Peptide显著减少体内β淀粉样蛋白的沉积，完全阻止淀粉样蛋白原纤维的形成。目前的证据表明，β-淀粉样蛋白沉积或Aβ中间体在阿尔茨海默氏病（AD）患者的发病机制中发挥重要作用。β-Sheet Breaker Peptide可以抑制脑中β淀粉样蛋白的沉积，是治疗阿尔茨海默氏病的重要靶标。
β5抑制大鼠脑模型中淀粉样蛋白的形成。
Beta-Sheet Breaker Peptide iAβ5 inhibits amyloid formation in rat brain models.
β-Sheet Breaker Peptide iAß5 (Bulk) is a peptide that inhibits the formation of β-sheets in proteins. It has been shown to be an excellent inhibitor of protein interactions, with good selectivity for its target. This peptide also has high purity and can be used as a research tool for studying the function of ion channels and antibodies.\n\n6-Fluoro-3-indoxyl-beta-D-galactopyranoside: Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through
"Beta-Sheet Breaker Peptide iAß5 is a peptide that interacts with amyloid beta proteins to disrupt the formation of beta sheets. It has been shown to inhibit the aggregation of amyloid beta proteins into oligomers and fibrils, and disrupts the self-assembly of amyloid beta protein into various conformations. Beta-Sheet Breaker Peptide iAß5 is a ligand for both receptor and activator binding sites on amyloid beta proteins, inhibiting the interaction of these sites. This inhibits the activation of downstream signalling pathways associated with Alzheimers disease."
| DOI | 名称 | |
|---|---|---|
| 10.1038/sj.mp.4001516 | Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits | 下载 |
| 10.1007/s00894-009-0594-y | Exploration of the mechanism for LPFFD inhibiting the formation of beta-sheet conformation of A beta(1-42) in water | 下载 |
| 10.1002/jmr.1113 | Effect of the beta-sheet-breaker peptide LPFFD on oriented network of amyloid β25-35 fibrils | 下载 |
| 10.1021/jp1116728 | Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity | 下载 |
| 10.1038/nm0798-822 | Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy | 下载 |
| 10.1016/j.bbrc.2009.01.090 | Design and biological activity of beta-sheet breaker peptide conjugates | 下载 |
