131602-53-4,淀粉肽Amyloidβ- Protein (25-35)、Aβ25-35,H2N-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH,H2N-GSNKGAIIGLM-OH,安徽专肽生物的产品

淀粉肽Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)
淀粉样蛋白具有神经营养和神经毒性作用的生物活性结构域位于β（25-35）序列GSNKGAIGLM中，该序列与速激肽家族肽中的一个区域同源。

编号：155032

CAS号：131602-53-4

单字母：H2N-GSNKGAIIGLM-OH

编号:	155032
中文名称:	淀粉肽Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)
英文名:	Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)
CAS号:	131602-53-4
单字母:	H2N-GSNKGAIIGLM-OH
三字母:	H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Gly 甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -Ser L-丝氨酸：serine。系统命名为(2S)-氨基-3-羟基丙酸。是编码氨基酸。因可从蚕丝中获得而得名。符号：S，Ser。在丝原蛋白及某些抗菌素中含有 D-丝氨酸。 -Asn 天冬酰胺：asparagine。L-天冬酰胺的系统命名为(2S)-氨基-3-氨酰基丙酸，是编码氨基酸。符号：N，Asn。D-天冬酰胺存在于短杆菌肽A分子中。 -Lys L-赖氨酸：lysine。系统命名为(2S)-6-二氨基已酸。是编码氨基酸中的碱性氨基酸，哺乳动物的必需氨基酸。在蛋白质中的赖氨酸可以被修饰为多种形式的衍生物。符号：K，Lys。 -Gly 甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -Ala 丙氨酸：alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸，是编码氨基酸，也叫L-α-丙氨酸。符号：A，Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -Ile L-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -Ile L-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -Gly 甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -Leu L-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -Met L-甲硫氨酸：methionine又称“蛋氨酸”。系统命名为(2S)-氨基-4-甲硫基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：M，Met。 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	11
分子式:	C₄₅H₈₁N₁₃O₁₄S₁
平均分子量:	1060.27
精确分子量:	1059.57
等电点(PI):	-
pH=7.0时的净电荷数:	1.97
平均亲水性:	-0.4625
疏水性值:	0.65
外观与性状:	白色粉末状固体
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
纯度:	95%、98%
盐体系:	可选TFA、HAc、HCl或其它
生成周期:	2-3周
储存条件:	负80℃至负20℃
标签:	未分类肽

β-Amyloid (25-35)是阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35)片段。

The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.

β-淀粉样蛋白通常存在于阿尔茨海默病(AD) 患者的大脑中，是老年痴呆症淀粉样斑块的主要组成部分。人大脑中β-淀粉样蛋白的主要存在形式是Aβ (1-40) 和Aβ (1-42)。然而研究发现存在于老年人脑中的Aβ(25 - 35)片段由于其特有的聚合性，毒性更大，与阿尔茨海默病(AD)息息相关。

Aβ(25-35) 由于其神经毒害作用被认为是Aβ的功能域，它是β-淀粉样蛋白的生物活性区域。研究表明小鼠侧脑室注射Aβ(25-35)片段可导致小鼠失忆，引起小鼠空间学习记忆能力障碍，并伴随被动回避反应的衰退。

在体内，Aβ (25-35)存在于阿尔茨海默病(AD)患者脑中下托及内嗅皮质神经元中[7]，也存在于包涵体肌炎(IBM)患者的肌肉中。

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淀粉肽Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)
淀粉样蛋白具有神经营养和神经毒性作用的生物活性结构域位于β（25-35）序列GSNKGAIGLM中，该序列与速激肽家族肽中的一个区域同源。

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淀粉肽Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)淀粉样蛋白具有神经营养和神经毒性作用的生物活性结构域位于β（25-35）序列GSNKGAIGLM中，该序列与速激肽家族肽中的一个区域同源。

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淀粉肽Amyloid β- Protein (25-35)、Aβ25-35、Amyloid beta-peptide (25-35)
淀粉样蛋白具有神经营养和神经毒性作用的生物活性结构域位于β（25-35）序列GSNKGAIGLM中，该序列与速激肽家族肽中的一个区域同源。